BRD4 (BD1), Active
Recombinant human BRD4 (BD1) (49-170) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. B18-31H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| B18-31H-50 | 50 ug | $205 | |
| B18-31H-100 | 100 ug | $305 | |
| B18-31H-BULK | BULK | Contact Us |
Recombinant human BRD4 (BD1) (49-170) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. B18-31H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| B18-31H-50 | 50 ug | $205 | |
| B18-31H-100 | 100 ug | $305 | |
| B18-31H-BULK | BULK | Contact Us |
Overview:
Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) protein family. BRD4 contains two tandem bromodomains: BD1 and BD2. BRD4 (BD1) functions as an epigenetic reader – recognizing and interpreting histone acetylation marks to recruit transcriptional machinery and chromatin remodeling complexes. BRD4 (BD1) is involved in the regulation of cell cycle progression, with its overexpression promoting cell proliferation and survival. Furthermore, it has been implicated in the development and progression of cancer as it regulates the expression of oncogenes and tumor suppressor genes.
Genbank Number:
References:
1. Wu T, Pinto HB, Kamikawa YF, et al. The BRD4 BD1-BD2 interface regulates transcriptional output of BET inhibitors. Nat Chem Biol. 2020;16(6):619-627. doi:10.1038/s41589-020-0522-0.
2. Filippakopoulos P, Qi J, Picaud S, et al. Selective inhibition of BET bromodomains. Nature. 2010;468(7327):1067-1073. doi:10.1038/nature09504.
3. Shi J, Wang Y, Zeng L, et al. Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014;25(2):210-225. doi:10.1016/j.ccr.2014.01.030
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
|
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
|
Alternative Name(s):
Bromodomain containing 4, BRD4, HUNK1, MCAP
Storage and Stability:
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~15 kDa. Calculated MW ~14.7 kDa.
There are no related publications available for this product.
STAY CONNECTED
Fax: 1-604-232-4601
BRD4 (BD2), Active, B18-38H
Toll Free: 1-866-954-6273
info@signalchem.com