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MLK4, Active

Recombinant human MLK4 (114-420) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M48-11G

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Catalog No. Pack Size Price (USD)
M48-11G-05 5 ug $226
M48-11G-10 10 ug $325
M48-11G-BULK BULK Contact Us  


MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas (1). MLK4 is a negative regulator of TLR4 (2).

Gene Aliases:

dJ862P8.3; KIAA1804; RP5-862P8.2; MAP3K21

Genbank Number:


1. Nagase, T.et.al;: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001.

2. Seit-Nebi, A. et.al: MLK4 has negative effect on TLR4 signaling. Cell. Molec. Immun. 9: 27-33, 2012.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~61 kDa

There are no related publications available for this product.


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