Recombinant human EPHB3 (585-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E23-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E23-11G-05 | 5 ug | $226 | |
E23-11G-10 | 10 ug | $325 | |
E23-11G-BULK | BULK | Contact Us |
Overview:
EPHB3 is a member of the Ephrin receptor family and is expressed during embryonic development in multiple regions of the central nervous system. In adult brain, EPHB3 is expressed in the cerebellum, raphe pallidus, hippocampus, entorhinal cortex, and both motor and sensory cortices (1). EPHB3 is involved in the maintenance of mature neuronal connections and/or re-arrangement of synaptic connections during late stages of development. EPHB3 plays a role in the regulation of cell adhesion and migration, and the catalytic activity of EPHB3 is required for inhibition of integrin-mediated cell adhesion (2).
Gene Aliases:
ETK2; HEK2; Cek10; Mdk5; TYRO6
Genbank Number:
References:
1. Willson, CA. et al: EphB3 receptor and ligand expression in the adult rat brain. J Mol Histol. 2006 Nov;37(8-9):369-80.
2. Miao, H. et al: Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J Biol Chem. 2005 Jan 14;280(2):923-32.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~68 kDa
There are no related publications available for this product.
Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases
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