Overview:

VAV1 (Vav guanine nucleotide exchange factor 1) is a cytoplasmic signal transducer protein that plays a crucial role in immune cell signaling, particularly in T-cell activation. It acts as a guanine nucleotide exchange factor (GEF) for the Rho family of GTPases, such as Rac1, Rac2, and RhoA, which are essential regulators of cell signaling, cytoskeletal organization, and cell migration. SH3 domains are approximately 50-70 amino acids in length that are known to mediate protein-protein interactions, often with proline-rich motifs in target proteins. The SH3 domain within VAV1 is essential for its protein-protein interactions, allowing it to interact with specific binding partners, regulate its GEF activity, and ultimately influence downstream signaling pathways involved in immune responses and cell signaling.

Genbank Number:

NM_005428.4

References:

1. Bustelo XR. Vav family exchange factors: an integrated regulatory and functional view. Small GTPases. 2014;5:e973757. doi:10.4161/sgtp.28001
2. Gakidis MA, Cullere X, Olson T, et al. Vav GEFs are required for β2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166(2):273-282. doi:10.1083/jcb.200401045
3. Katzav S. Vav1: a Dr. Jekyll and Mr. Hyde protein - good for the hematopoietic system, bad for cancer. Oncotarget. 2015;6(37):38444-38457. doi:10.18632/oncotarget.5717