Recombinant 2019-nCoV Spike protein S1 (∆Y145, ∆H146, E484K, D614G) (16-685) was expressed in CHO cells using a C-terminal His- tag.
Catalog No. C19S1-G231DH
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C19S1-G231DH-10 | 10 ug | $100 | |
C19S1-G231DH-20 | 20 ug | $190 | |
C19S1-G231DH-50 | 50 ug | $290 | |
C19S1-G231DH-100 | 100 ug | $435 | |
C19S1-G231DH-BULK | BULK | Contact Us |
Overview:
Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world since 2020 (1). The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) and facilitate viral entry into the host cell (2). Highly transmissible B.1.617 variant identified in India has mutations (∆Y145, ∆H146, E484K, D614G) in the spike protein. These mutations may result in increased transmissibility and re-infection or resistance to vaccine-elicited antibody. As new variants emerge, it is pivotal to evaluate their transmissibility, virulence and their possible tendency to escape antibody neutralization (3).
Gene Aliases:
2019-nCoV s1, SARS-CoV-2 spike S1, SARS-CoV-2 S1, novel coronavirus spike s1, nCoV spike s1, coronavirus spike S1.
Genbank Number:
References:
1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89. 2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. Nature. 2020, 581:215-220. 3. Takuya T, et al: The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India Provide Partial Resistance to Vaccine-elicited and Therapeutic Monoclonal Antibodies. 2021. doi: https://doi.org/10.1101/2021.05.14.444076
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular weight:
130 kDa (calculated MW~76 kDa).
Purity:
Activity:
There are no related publications available for this product.
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