Recombinant full-length 2019-nCoV Nucleocapsid (N) Protein was expressed in E. coli cells with a C-terminal His tag.
Catalog No. C19NP-G242H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C19NP-G242H-10 | 10 ug | $100 | |
C19NP-G242H-20 | 20 ug | $190 | |
C19NP-G242H-50 | 50 ug | $290 | |
C19NP-G242H-100 | 100 ug | $435 | |
C19NP-G242H-BULK | BULK | Contact Us |
Overview:
CoV N-protein is an RNA-binding protein primarily involved in binding to the viral RNA genome during packaging of viral RNA into a helical ribonucleoproteins or nucelocapsid structure (1). In addition, N-protein regulates viral RNA synthesis during replication/transcription and modulates host-pathogen interactions, such as such as actin reorganization, host cell cycle progression, and apoptosis (2). N-protein is abundantly expressed during infection and antibodies against N-protein have been detected in confirmed cases of Covid-19. Therefore, N-protein is a potent antigen that provides basis for future vaccine and diagnostic kit development (3).
Gene Aliases:
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
Genbank Number:
References:
1. McBride R, et al: The coronavirus nucleocapsid is a multifunctional protein. Viruses. 2014, 6:2991-3018.
2. Surjit M, et al: The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem. 2006, 281:10669-10681
3. Zeng W, et al: Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 2020, 527(3):618‐623.
Specific Activity:
Binding of Anti-2019-nCoV N-Protein Antibody (C19NP-60H) to immobilized 2019-nCoV Nucleocapsid (N) Protein (C19NP-G242H) determined by ELISA using Goat anti-human Fc-HRP.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
52 kDa
There are no related publications available for this product.
Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Invasion/Metastasis, Lung Diseases , Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology
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