Recombinant Human Monoclonal IgG Antibody
Catalog No. C19NP-60DH
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C19NP-60DH-20 | 20 ug | $205 | |
C19NP-60DH-100 | 100 ug | $405 | |
C19NP-60DH-BULK | BULK | Contact Us |
Overview:
nCoV N-Protein / Nucleocapsid protein is an RNA-binding protein primarily involved in binding to the viral RNA genome during packaging of viral RNA into a helical ribonucleoprotein or nucleocapsid structure (1). In addition, N-protein regulates viral RNA synthesis during replication/transcription and modulates host-pathogen interactions, such as actin reorganization, host cell cycle progression, and apoptosis (2). N-Protein is abundantly expressed during infection and antibodies against N-Protein have been detected in confirmed cases of Covid-19. Therefore, N-Protein is a potent antigen that provides basis for future vaccine and diagnostic kit development (3).
References:
1. McBride R, et al: The coronavirus nucleocapsid is a multifunctional protein. Viruses. 2014, 6:2991-3018.
2. Surjit M, et al: The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem. 2006, 281:10669-10681.
3. Zeng W, et al: Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 2020, 527(3):618‐623.
Specificity :
Recognizes the 2019-nCoV N-Protein
Cross Reactivity:
SARS-CoV N-Protein
Host Isotype/Clone#:
Human IgG
Stability :
1yr at –20oC from date of shipment
Assay Data :
Binding of Anti-2019-nCoV N-protein, HRP-conjugated (C19NP-60DH) to immobilized 2019-nCoV RBD-N Protein Chimera (C19NSD-G241H) determined by ELISA
There are no related publications available for this product.
Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Metabolic Disorder, Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology
STAY CONNECTED
Fax: 1-604-232-4601