Recombinant Human Monoclonal IgM Antibody
Catalog No. C19S1-M60H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C19S1-M60H-20 | 20 ug | $165 | |
C19S1-M60H-100 | 100 ug | $325 | |
C19S1-M60H-BULK | BULK | Contact Us |
Overview:
The severe acute respiratory syndrome related novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) (3). A receptor binding domain (RBD) of S1 can recognize the cell surface receptor and the mutation of RBD could cause higher motility rate (3).
References:
1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.
2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.
3. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235
Specificity:
Recognizes the 2019-nCoV Spike protein
Cross Reactivity:
SARS-CoV Spike protein
Host Isotype / Clone#:
Human, IgM
Stability:
1yr at –20oC from date of shipment.
Assay Data:
Sample Activity Plot. For specific information on a given lot, see the related technical datasheet.
There are no related publications available for this product.
Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Inflammation, Lung Diseases , Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology
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