Recombinant full-length human STAT5B was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. S56-54BH
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S56-54BH-20 | 20 ug | $215 | |
S56-54BH-50 | 50 ug | $435 | |
S56-54BH-BULK | BULK | Contact Us |
Overview:
STAT5B or signal transducer and activator of transcription 5B is a member of the STAT family of transcription factors. STATs are phosphorylated by the receptor associated kinases and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B is activated in response to a variety of cytokines (1). The JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development (2). STAT5B is critical for maintenance of tolerance in vivo and it is proposed that STAT5B is probably activated by IL2R.
Gene Aliases:
STAT5
Genbank Number:
References:
1. Wang, D.et.al: Naturally occurring dominant negative variants of Stat5.Molec. Cell Biol. 16: 6141-6148, 1996.
2. Wawersik, M.et.al: Somatic control of germline sexual development is mediated by the JAK/STAT pathway. (Letter) Nature 436: 563-567, 2005.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~95 kDa
A. Cumaraswamy Abbarna et al., Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein ACS Medical Chemistry Letters September 2014 10.1021/ml500165r
Zeidan N et al., Magnetic bead-based electrochemical detection of interaction between epigallocatechin-3-gallate and STAT proteins Analytical Methods March 2015 10.1039/c5ay00169b
Zhanga Xiaolei et al., Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts PNAS January 2012 10.1073/pnas.1121606109
Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway
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