Full-length recombinant human KAT5 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K314-380G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
K314-380G-05 | 5 ug | $259 | |
K314-380G-10 | 10 ug | $380 | |
K314-380G-BULK | BULK | Contact Us |
Overview:
KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins (1). KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis (2).
Gene Aliases:
cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60
Genbank Number:
References:
1. Kamine, J. et.al: Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transcriber. Virology 216: 357-366, 1996.
2. Gorrini, C. et.al: Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature 448: 1063-1067, 2007.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~88 kDa
A. Krukenberg Kristin et al., Basal Activity of a PARP1-NuA4 Complex Varies Dramatically across Cancer Cell Lines Cell Reports September 2014 10.1016/j.celrep.2014.08.009
Eichele G et al., Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters
eLife July 2019 10.7554/eLife.43235
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway
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