Home   >    Enzymes   >   Kinases

CDK12 (CRKRS) Protein

Recombinant human CDK12 (658-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C62-35G


Shop Online



Catalog No. Pack Size Price (USD)
C62-35G-20 20 ug $215
C62-35G-50 50 ug $435
C62-35G-BULK BULK Contact Us  


Overview:

CDK12 forms a protein complex with cyclin K and this complex acts at the level of RNA polymerase II (RNAPII) to regulate expression of long complex genes, several of which play a role in DNA maintenance and repair. CDK12 is highly expressed in adult liver, kidney, testis, ovary, spinal cord and within specific adult brain regions with the highest expression being detected in cerebellum and caudate nucleus (1). CYCK-CDK12 and CYCK-CDK13 complexes show unique function with the CYCK-CDK12 playing a role in maintenance of genomic stability (2).


Gene Aliases:

CDK12: CDK12; CRKRS; CRK7; CRKR; KIAA0904


Genbank Number:


References:


1. Ko, T. K.et.al: CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell Sci. 114: 2591-2603, 2001.

2. Blazek, D.et.al: The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25: 2158-2172, 2011.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~135kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  CDK1/CyclinA1, Active, C22-18BG

  CDK2/CyclinE1, Active, C29-18G

  CDK4/CyclinD3, Active, C31-18G

  CDK9/CyclinK, Active, C40-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox