Recombinant human ROS1 (G2101A) (1881-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R14-12EG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R14-12EG-05 | 5 ug | $226 | |
R14-12EG-10 | 10 ug | $325 | |
R14-12EG-BULK | BULK | Contact Us |
Overview:
ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines (1). The resulting ROS1/FIG fusion protein is a constitutively activated tyrosine kinase. Direct interaction of ROS1 and the phosphatase SHP-1 can lead to efficient downregulation of ROS1-mediated signaling (2). Binding sites in the ROS1 cytoplasmic domain display high affinity binding to the SHP-1 N-terminal SH2 domain.
Gene Aliases:
c-ros-1; MCF3; ROS
Genbank Number:
References:
1. Charest, A. et al: Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer 37: 58-71, 2003.
2. Biscup, C. et al: Visualization of SHP-1-target interaction. J Cell Sci. 2004 Oct 1;117(Pt 21):5165-78.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
82 kDa
There are no related publications available for this product.
Cancer, Metabolic Disorder, Receptor Tyrosine Kinases
STAY CONNECTED
Fax: 1-604-232-4601