Recombinant human AAK1 (1-465) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A01-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A01-11G-05 | 5 ug | $226 | |
A01-11G-10 | 10 ug | $325 | |
A01-11G-BULK | BULK | Contact Us |
Overview:
Adaptor-associated kinase 1 (AAK1) is a serine/threonine protein kinase of the NAK kinase. Along with GAK, AAK1 regulates clathrin-mediated endocytosis by phosphorylating the μ subunits of both AP-1 and AP-2 trafficking adaptors. The phosphorylation increases the affinity of AP2 for membranes and induces a conformational change enabling cargo recruitment by this adaptor. AAK1 was also shown to play a positive role in regulating the Notch pathway.
Gene Aliases:
KIAA1048
Genbank Number:
References:
1. Gupta-Rossi N, et al. The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. J Biol Chem. 286(21):18720-30, 2011.
2. Conner SD, Schmid SL. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol. 156(5):921-9, 2002.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
78 kDa
There are no related publications available for this product.
Cancer, Neurobiology, Ser/Thr Kinases
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