Full-length recombinant human PDE7B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P95-30BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P95-30BG-05 | 5 ug | $259 | |
P95-30BG-10 | 10 ug | $380 | |
P95-30BG-BULK | BULK | Contact Us |
Overview:
PDE7B is a cAMP-specific phosphodiesterase and a member of the cyclic nucleotide phosphodiesterase family that catalyzes the hydrolysis of cAMP to the corresponding 5'-monophosphate and provides a mechanism to downregulate cAMP signaling (1). PDE7B is over-expressed in chronic lymphocytic leukemia and inhibition of PDE7B leads to induction of apoptosis (2). PDE7B has been identified as a candidate gene for measuring treatment response to risperidone and may confer susceptibility to schizophrenia.
Gene Aliases:
MGC88256; bA472E5.1
Genbank Number:
References:
1. Hetman, J. M. et.al: Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc. Nat. Acad. Sci. 97: 472-476, 2000.
2. Ikeda, M. et al: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry. 2010 Feb 1;67(3):263-9.
Specific Activity:
Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~73 kDa
There are no related publications available for this product.
Cardiovascular Disease, Inflammation, Phosphodiesterases
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