Recombinant full-length human MNK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. M55-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M55-10G-05 | 5 ug | $226 | |
M55-10G-10 | 10 ug | $325 | |
M55-10G-BULK | BULK | Contact Us |
Overview:
MNK2 (MAP kinase-interacting kinase 2) contains a conserved C-terminal ERK-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain. MNK2 binds tightly to the growth factor-regulated MAP kinases, ERK1 and ERK2. ERK and p38 phosphorylate MNK2, which stimulates its in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E) (1). A yeast two-hybrid screen showed the Mnk2 protein interacted with the ligand-binding domain of estrogen receptor beta (ERbeta) (2).
Gene Aliases:
MKNK2; GPRK7
Genbank Number:
References:
1. Waskiewicz, A J. et al: Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997 Apr 15;16(8):1909-20.
2. Slentz-Kesler, K. et al: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. Genomics. 2000 Oct 1;69(1):63-71.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~74 kDa
There are no related publications available for this product.
Angiogenesis, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, p38 Pathway, Ser/Thr Kinases
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