Recombinant full-length mouse DGKA was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D21-10CG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D21-10CG-05 | 5 ug | $226 | |
D21-10CG-10 | 10 ug | $325 | |
D21-10CG-BULK | BULK | Contact Us |
Overview:
Diacylglycerol kinase alpha (DAG kinase alpha) is a member of the eukaryotic diacylglycerol kinase family. Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Involved in hepatocellular carcinoma progression through regulation of the Ras/Raf/MEK/ERK pathway. The DGKα/atypical PKC/β1 integrin signaling pathway is required for matrix invasion of breast carcinoma cells.
Gene Aliases:
AW146112; Dagk1
Genbank Number:
References:
1. Takeishi, K. et al. (2012). Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway. J. Hepatol. 57, 77–83. 2. Rainero, E. et al. (2014). The diacylglycerol kinase alpha/atypical PKC/beta1 integrin pathway in SDF-1alpha mammary carcinoma invasiveness. PLoS ONE 9:e97144. 3. Sakane F, et al. (2016). Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update. Front Cell Dev Biol. 4:82.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity data. For specific information on a given lot, see related technical data sheet.
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular weight:
approx. MW 109 kDa
There are no related publications available for this product.
Cancer, Lipid Kinases, Neurobiology
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