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p21CIP1 Protein

Recombinant full-length human p21CIP1 was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. C27-30G


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Catalog No. Pack Size Price (USD)
C27-30G-50 50 ug $435
C27-30G-20 20 ug $215
C27-30G-BULK BULK Contact Us  


Overview:

CIP 1 (Cyclin-Dependent Kinase Inhibitor 1A) regulates cell cycle progression, terminal differentiation, and apoptosis (1). CIP1 was shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinase (CDK) activity. DNA damage leads to increased expression of CIP1 in cyclin E-containing complexes and to an associated decrease in cyclin-dependent kinase activity. CIP1 is a critical downstream effector in the p53-specific pathway of growth control in mammalian cells (2).


Gene Aliases:

CDKN1A, P21, SDI1, WAF1, CAP20, CDKN1, MDA-6


Genbank Number:


References:


1. el-Deiry, W S. et al: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994;54(5):1169-74

2. Wagner, M. et al: Cyclin-dependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: possible implications of molecular biology and compartmentation. Anticancer Res. 2001; 21(1A):333-45.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~46 kDa



RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


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  CDK3, Unactive, C30-14G

  CDK7, Unactive, C36-14G


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