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p18INK4C Protein

Recombinant full-length human p18INK4C was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. C32-30G


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Catalog No. Pack Size Price (USD)
C32-30G-50 50 ug $435
C32-30G-20 20 ug $215
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Overview:

p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6 (1). Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells (2).


Gene Aliases:

CDKN2C, p18, INK4C, p18-INK4C


Genbank Number:


References:


1. Ravichandran, N. et al: Structure-based Design of p18INK4c Proteins with Increased Thermodynamic Stability and Cell Cycle Inhibitory Activity. J. Biol. Chem., 2002; 277: 48827-48833.

2. Sánchez-Aguilera,A. et al: Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. Blood. 2004;103(6):2351-7.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~42 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


  p21CIP1 Protein, C27-30G

  TAOK2, Active, T25-11G

  p19INK4D Protein, C33-30G

  CDK4, Unactive, C31-14BG


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