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CDK2 Protein

Recombinant full-length human CDK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C29-30G


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Catalog No. Pack Size Price (USD)
C29-30G-20 20 ug $215
C29-30G-50 50 ug $435
C29-30G-BULK BULK Contact Us  


Overview:

CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) (1). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition (2).


Gene Aliases:

p33 (CDK2)


Genbank Number:


References:


1. Levkau, B. et al: Cleavage of p21 (Cip1/Waf1) and p27 (Kip1) mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Molec. Cell 1: 553-563, 1998.

2. Huang, H. et al: CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314: 294-297, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~58 kDa



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  CDK3/CyclinE1, Active, C30-10G

  CDK6/CyclinD3, Active, C35-10H

  CDK7/CyclinH1/MNAT1, Active, C36-10H

  CDK7, Unactive, C36-14G


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