CyclinA2 belongs to the highly conserved cyclin family whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle and function as regulators of CDKs. CyclinA2 is an essential component of all embryonic and somatic cell cycles in mammals (1). CyclinA2 is highly expressed in the testis and certain myeloid leukemia cells (2). Cyclin A also plays a major role in the control of DNA replication (3). CyclinA2 binds and activates CDC2 or CDK2 and thus promotes both cell cycle G1/S and G2/M transitions.
CCNA2; CCN1; CCNA
1. Murphy, M.et.al: Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nature Genet. 15: 83-86, 1997.
2. Yang, R.et.al: Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. 57: 913-920, 1997.
3. Girard, F. et.al: Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67: 1169-1179, 1991.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cell Cycle