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CDK5P35 Protein

Recombinant full-length human CDK5P35 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C34-30G


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Catalog No. Pack Size Price (USD)
C34-30G-20 20 ug $215
C34-30G-50 50 ug $435
C34-30G-BULK BULK Contact Us  


Overview:

CDK5P35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) that bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle .The activation of CDK5 is required for proper development of the central nervous system. p35 is a regulatory subunit for CDK5 which is proteolytically cleaved by calpain and generating a p25 form that involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases (1). Cdk/p35 plays a role in primary afferent nociceptive signaling and is required for cortical plate neurons to migrate past preexisting neurons and take up superficial positions to constitute the inside-outside layering order of cortical lamination(2).


Gene Aliases:

p35, CDK5R1, CDK5R, NCK5A,p35nck5a


Genbank Number:


References:


1. Patrick, G. N.et.al: Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402: 615-622, 1999.

2. Chae, T. et.al: Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18: 29-42, 1997.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~60 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  CDK5P25 Protein, C34-31G

  CDK4, Unactive, C31-14BG

  CDK7, Unactive, C36-14G

  CDK20 (CCRK) Protein, C21-30G


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