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CyclinE1 Protein

Recombinant full-length human CyclinE1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C82-30G


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Catalog No. Pack Size Price (USD)
C82-30G-20 20 ug $215
C82-30G-50 50 ug $435
C82-30G-BULK BULK Contact Us  


Overview:

Cyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle that functions as regulators of CDK kinases. Cyclin E1 activity is required for centrosome duplication during S phase and this mechanism could coordinate centrosome reproduction with cycles of DNA synthesis and mitosis (1). The downregulation of cyclin E-CDK2 kinase activity following the G1/S-phase transition that is necessary for the maintenance of karyotypic stability. Cyclin E also has a modular centrosomal-targeting domain which is essential for promoting S phase entry in a Cdk2-independent manner (2).


Gene Aliases:

CCNE1, CCNE


Genbank Number:


References:


1. Hinchcliffe, E. H. et.al: Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283: 851-854, 1999.

2. Matsumoto, Y.et.al: A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science 306: 885-888, 2004.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


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  CyclinH Protein, C83-30H

  Cyclin Y Protein, C87-30G


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