Cyclin Y belongs to the highly conserved cyclin family. The members of the cyclin family are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclin Y plays an important role in the processes of transcription, DNA repair, and cell cycle progression. Cyclin Y regulates cyclin-dependent kinases (1). Cyclin Y is an isoform of CCNY that is also known as CFP1 variant A which has a calculated molecular mass of 36.9 kD. (2). Cyclin Y specifically activates transcription through the MYC promoter.
CCNY; C10orf9; CBCP1; CCNX; CFP1
1. Li, X. et.al: Identification and characterization of cyclin X which activates transcriptional activities of c-Myc. Molec. Biol. Rep. 36: 97-103, 2009.
2. Myc. Molec. Biol. Rep. 36: 97-103, 2009. Deloukas, P. et.al: DNA sequence and comparative analysis of human chromosome 10. Nature 429: 151-157, 2004.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cell Cycle