Recombinant human GRB2 SH3-1 domain (2-64) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. G45-351G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
G45-351G-20 | 20 ug | $215 | |
G45-351G-50 | 50 ug | $435 | |
G45-351G-BULK | BULK | Contact Us |
Overview:
The Growth Factor Receptor-Bound Protein 2 (GRB2) is an important adapter protein involved in intracellular signaling pathways, particularly in receptor tyrosine kinase (RTK) signaling. It contains multiple domains, including the Src homology 3 (SH3) domains. The GRB2 SH3-1 domain is a specific SH3 domain within the GRB2 protein. SH3 domains are approximately 50-70 amino acids in length and play a critical role in mediating protein-protein interactions. They typically bind to proline-rich motifs in target proteins, facilitating the assembly of signaling complexes and contributing to various cellular processes, including signal transduction, cytoskeletal organization, and cell proliferation.
Genbank Number:
References:
1. Buday L, Downward J. Many faces of Ras activation. Biochim Biophys Acta. 2008;1786(2):178-187. doi:10.1016/j.bbcan.2008.05.003
2. Lowenstein EJ, et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992;70(3):431-442. doi:10.1016/0092-8674(92)90167-B
3. McDonald CB, et al. Structural insights into the binding of the human receptor tyrosine kinase MET by its ligand stromal cell-derived factor 1α (SDF-1α). J Biol Chem. 2015;290(13):7719-7732. doi:10.1074/jbc.M114.631126
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Alternative Name(s):
ASH
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~33 kDa. Calculated MW ~33 kDa.
There are no related publications available for this product.
Cell Cycle
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