Full-length recombinant human SIRT7 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. S41-30H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S41-30H-05 | 5 ug | $259 | |
S41-30H-10 | 10 ug | $380 | |
S41-30H-BULK | BULK | Contact Us |
Overview:
SIRT7 is a member of the class IV of sirtuin family of proteins which are homologs to the yeast Sir2 protein and play a role in cell differentiation, proliferation, apoptosis, metabolism, and senescence. SIRT7 associates with active rRNA genes and histones. Overexpression of SIRT7 increases pol I-mediated transcription whereas knockdown of SIRT7 or inhibition of its catalytic activity results in decreased association of pol I with rDNA and reduced pol I transcription (1). Depletion of SIRT7 stops cell proliferation and triggers apoptosis. SIRT7 deacetylates p53 and increases cellular resistance to cytotoxic and oxidative stress (2).
Gene Aliases:
SIR2L7, MGC126840, MGC126842
Genbank Number:
References:
1. Ford, E. et al: Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20: 1075-1080, 2006.
2. Vakhrusheva, O. et al Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102: 703-710, 2008.
Specific Activity:
Sample SIRT Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~46 kDa
zhao J et al., SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway
Journal of Experimental & Clinical Cancer Research April 2019 10.1186/s13046-019-1246-4
Z Li et al., The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. Oncogene September 2016 10.1038/onc.2016.359
Cancer, Cell Cycle, Inflammation
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