Tyrosine kinase inhibitor
Catalog No. K11-900B
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An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation (1). Inhibits the growth of a number of cancer cell lines (2). An extremely useful tool for exploring EGF-mediated cellular signaling (3).
1. DW Fry et al. Science 1994 265:1093
2. M Bos et al. Clin. Cancer Res. 1997 3:2099
3. MP Tetreault et al. J. Cell. Biochem. 2008 105:1240
CAS Registry Number:
C16H14BrN3O2 ∙ HCl
White to off-white solid
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (5 mg/ml, warm)
1. 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.
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Cancer, Metabolic Disorder, Ser/Thr Kinases