Recombinant human CLK1 (129-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C57-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C57-11G-05 | 5 ug | $226 | |
C57-11G-10 | 10 ug | $325 | |
C57-11G-BULK | BULK | Contact Us |
Overview:
CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins (1), such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors (2).
Gene Aliases:
CLK, STY, CLK/STY
Genbank Number:
References:
1. Prasad J et al: Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol. 2003 Jun; 23(12): 4139-49.
2. Colwill, K. et al: SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J. Biol. Chem. 271: 24569-24575, 1996.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66 kDa
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases
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