Recombinant human HER3 (667-1020) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. E28-35H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E28-35H-20 | 20 ug | $215 | |
E28-35H-50 | 50 ug | $435 | |
E28-35H-BULK | BULK | Contact Us |
Overview:
HER3 is a member of the human epidermal growth factor receptor (EGFR/HER) tyrosine kinase family whose kinase domain lacks several residues critical for catalysis but serves as an activator of the EGFR kinase domain (1,2). Phosphorylation of HER3 by other EGFR family members, most commonly HER2, activates the PI3K/AKT pathway (2). In cancer cells treated with HER2 kinase inhibitors, diminished HER2 activity is compensated for by HER3 overexpression, resulting in tumor cell survival (2).
Genbank Number:
References:
1. Shi, F. et al: ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc Natl Acad Sci USA 107(17): 7692-7697, 2010.
2. Jura, N. et al: Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci USA 106(51): 21608-21613, 2009.
Alternative Name(s):
ERBB3
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Molecular Weight:
Calculated MW ~41 kDa.
There are no related publications available for this product.
Cancer, Cell Cycle, Cellular Stress, Receptor Tyrosine Kinases
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