Recombinant full-length human MYT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. M67-10H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M67-10H-05 | 5 ug | $226 | |
M67-10H-10 | 10 ug | $325 | |
M67-10H-BULK | BULK | Contact Us |
Overview:
MYT1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins which binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system (1). The recombinant MYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn (2+), but not other divalent cations (2).
Genbank Number:
References:
1. Kim, J. G. et.al: Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J. Neurosci. Res. 50: 272-290, 1997.
2. Kim, J. G. et.al: Novel member of the zinc finger superfamily: a C (2)-HC finger that recognizes a glia-specific gene. Molec. Cell. Biol. 12: 5632-5639, 1992.
Alternative Name(s):
PKMYT1, PPP1R126
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Molecular Weight:
Observed MW ~65 kDa.
Calculated MW ~58.7 kDa.
There are no related publications available for this product.
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