Recombinant full-length isoform 1 of human Diacylglycerol kinase gamma (DGKG) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D25-10BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D25-10BG-05 | 5 ug | $226 | |
D25-10BG-10 | 10 ug | $325 | |
D25-10BG-BULK | BULK | Contact Us |
Overview:
Diacylglycerol kinase gamma (DGKG) is a member of DGK type I subfamily which have EF-hand motifs and two cysteine-rich regions (C1 domain) in the regulatory domain. These enzymes catalyze the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins such as protein kinase C isoforms and RAS guanyl nucleotide-releasing proteins and some transient receptor potential channels. (1) DGKG has been associated with malignancies with its role as tumor suppressor in colorectal cancer. (2) DGKG is also implicated in regulation of cell cycle regulation. (3)
Gene Aliases:
Diglyceride kinase gamma, DGKgamma, DAGK3, DAGKgamma,
Genbank Number:
References:
1. Sakane, F. et al. (1997) Diacylglycerol kinase J. Biol. Chem. 29, 1139-1143. 2. Kai, M.et al (2017). Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer. Mol. Carcinog. 56, 1743-1752. 3. Matsubara, T. et al. (2006). Nuclear transportation of diacylglycerol kinase γ and its possible function in the nucleus. J. Biol. Chem. 281, 6152-6164.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular weight:
120 kDa
There are no related publications available for this product.
Cancer, Neurobiology
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