Anti-Phospho-Rel A (ser276)
Rabbit Polyclonal Antibody
Catalog No. R29-365R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R29-365R-100 | 100 ul | $675 | |
| R29-365R-BULK | BULK | Contact Us |
Rabbit Polyclonal Antibody
Catalog No. R29-365R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R29-365R-100 | 100 ul | $675 | |
| R29-365R-BULK | BULK | Contact Us |
Overview:
Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses In unstimulated cells, NF-κB is sequestered in the cytoplasm by its inhibitory proteins, the IκBs (1). NF-κB-activating agents can induce the phosphorylation of IκB’s, targeting them for rapid degradation through an ubiquitin-proteasome pathway, releasing NF-κB to enter the nucleus, where it regulates gene expression.
References:
1. Baeuerle, P. et al: Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994;12:141-79.
Specificity:
Recognizes the human p65 protein phosphorylated at Serine 276
Cross Reactivity:
Human
Host Isotype / Clone#:
Rabbit, Antiserum
Immunogen:
The antibody was produced against synthesized peptide corresponding to a region near phosphorylated Ser276 of the protein conjugated to KLH.
Purification:
Delipidation and defibrination
Stability:
1yr at –20oC from date of shipment
Sample Data:
Western Blot of total protein lysates from head and neck tumors using anti-Phospho-Rel A (Ser276) antibody. Lanes 1-6: squamal carcinoma cells. Lane 7: primary culture of human keratinocytes Lane 8: ATCC SCC9 cells (also a head and neck squamal carcinoma). Lane 9: EGF-induced human derived A431 cells.
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Sample Data:
Anti-pS529 shows phospho p65 staining in carcinoma cells.
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There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Inflammation, Neurobiology, NfkB Pathway
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