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Anti-phospho-JAK1 (Tyr1022)

Rabbit Polyclonal Antibody
Catalog No. J01-65R




Catalog No. Pack Size Price (USD)
J01-65R-100 100 ug $325
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Overview:

JAK1 is a member of the Janus family of tyrosine kinases which are involved in cytokine receptor-mediated intracellular signal transduction (1). Upon stimulation by cytokines, JAK1 undergoes autophosphorylation. In turn, activated JAK1 is responsible for phosphorylating several signaling proteins, including STATs. Phosphorylated STATs dimerize and translocate to the nucleus where they regulate transcription of genes involved in growth, survival and differentiation. Phosphorylation of JAK1 at Tyr1022 and Tyr1023 is associated with cells that are undergoing proliferation (2).


Specificity:

Recognizes the JAK1 protein phosphorylated at tyrosine 1022


Cross Reactivity:

Human, Mouse and Rat


Host / Isotype / Clone#:

Rabbit, IgG


Immunogen:

Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1022


Purification:

Affinity chromatography


Stability:

Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Sample Data:

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-phospho-JAK1 (Tyr1022) antibody.


References :


1. Leonard, W J. et al : Jaks and STATs: biological implications. Annu Rev Immunol. 1998;16:293-322.

2. Trenarry, M K. et al : JAK/STAT signaling and human in vitro myogenesis. BMC Physiol. 2011 Mar 9;11:6.



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway



SIGNALCHEM BIOTECH INC.


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