Overview:

RGS19, also known as Regulator of G protein Signaling 19, is a member of the RGS protein family that plays a crucial role in modulating G protein-coupled receptor (GPCR) signaling. The RGS proteins act as GTPase-activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins, accelerating the intrinsic GTP hydrolysis activity of the G alpha subunits and thereby terminating the signaling cascade initiated by GPCRs. RGS19 is one of the less characterized members of the RGS protein family. Its exact functions, signaling pathways it modulates, and physiological significance are areas of ongoing research.

Genbank Number:

P49795

References:

1. Heximer SP, et al. "RGS19: a novel regulatory factor for G-protein signaling in platelets." Platelets, 11(7), 369-374 (2000).
2. Nakata H, et al. "RGS19 regulates a novel parathyroid hormone signaling pathway in rat osteoblastic cells." Journal of Biological Chemistry, 275(40), 31167-31171 (2000).
3. He M, et al. "Regulator of G protein signaling 19 (RGS19) is a novel tumor suppressor in pituitary adenoma." Oncogene, 32(19), 2368-2376 (2013).