Recombinant full-length human 4EBP1 Protein was expressed in Sf9 insect cells using an N-terminal His tag.
Catalog No. E35-54H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E35-54H-20 | 20 ug | $215 | |
E35-54H-50 | 50 ug | $435 | |
E35-54H-BULK | BULK | Contact Us |
Overview:
4EBP1 is a member of a family of translation repressor proteins that directly interact with eukaryotic translation initiation factor 4E (EIF4E). Interaction of 4EBP1 with EIF4E inhibits the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs thereby leading to repression of translation. Insulin treatment of adipose cells increases the phosphorylation of 4EBP1 and leads to reduced interaction of 4EBP1 with EIF4E (1). 4EBP1 is expressed in most tissues, with highest levels seen in adipose tissue, pancreas, and skeletal muscle (2).
Gene Aliases:
BP-1, EIF4EBP1, PHAS-I, MGC4316
Genbank Number:
References:
1. Pause, A. et al: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5-prime-cap function. Nature 371: 762-767, 1994.
2. Tsukiyama-Kohara, K. et al: Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics 38: 353-363, 1996.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~18 kDa
Ning Rui Yan et al., Huntingtin functions as a scaffold for selective macroautophagy Nature Cell Biology November 2014 10.1038/ncb3101
Kroczynska Barbara et al., Regulatory Effects of Ribosomal S6 Kinase 1 (RSK1) in IFNλ Signaling Journal of Biological Chemistry January 2011 10.1074/jbc.M110.183566
Shuda Masahiro et al., CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation PNAS March 2015 10.1073/pnas.1505787112
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