Recombinant full-length human USP15 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U515-380G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
U515-380G-05 | 5 ug | $226 | |
U515-380G-10 | 10 ug | $325 | |
U515-380G-BULK | BULK | Contact Us |
Overview:
USP15 (ubiquitin carboxyl-terminal hydrolase 15) is a member of the ubiquitin specific protease (USP) family of cysteine protease deubiquitination enzymes and regulates TGFB receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. The enzyme interacts with OP9 signalosome and is a key regulator of TGFB receptor signaling through deubiquitination of receptor-activated SMAD transcription factors (1). USP15 also plays a role in the regulation and stabilization of Human Papillomavirus (HPV) type 16 E6 protein, suggesting that E6 may be a target for USP15 DUB activity (2).
Gene Aliases:
KIAA0529, UNPH-2
Genbank Number:
References:
1. Inui, M. et al: USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 13(11):1368-75, 2011
2. Vos, Robin M et al: The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. Journal of virology 83(17): 8885-92, 2009.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
130 kDa
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder
STAY CONNECTED
Fax: 1-604-232-4601