Overview:

PRMT5 (Protein Arginine Methyltransferase 5) and its coactivator MEP50 (Methylosome Protein 50) form a complex that plays a crucial role in the methylation of arginine residues in proteins, a process known as arginine methylation. This complex has been implicated in the regulation of various cellular functions, including gene expression, RNA processing, and signal transduction. Aberrant expression and dysregulation of PRMT5 and MEP50 have been observed in various cancers, highlighting their potential roles in tumorigenesis.

Genbank Number:

NM_006109
BC001679

References:

1. Yang Y, Bedford MT. (2013) Protein arginine methyltransferases and cancer. Nat Rev Cancer. 13(1):37-50.
2. Blanc RS, Richard S. (2017) Arginine Methylation: The Coming of Age. Mol Cell. 65(1):8-24.
3. Stopa N, Krebs JE, Shechter D. (2015) The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cell Mol Life Sci. 72(11):2041-2059.