Overview:

The Growth Factor Receptor-Bound Protein 2 (GRB2) is an important adapter protein involved in intracellular signaling pathways, particularly in receptor tyrosine kinase (RTK) signaling. It contains multiple domains, including the Src homology 3 (SH3) domains. The GRB2 SH3-1 domain is a specific SH3 domain within the GRB2 protein. SH3 domains are approximately 50-70 amino acids in length and play a critical role in mediating protein-protein interactions. They typically bind to proline-rich motifs in target proteins, facilitating the assembly of signaling complexes and contributing to various cellular processes, including signal transduction, cytoskeletal organization, and cell proliferation.

Genbank Number:

NM_002086.5

References:

1. Buday L, Downward J. Many faces of Ras activation. Biochim Biophys Acta. 2008;1786(2):178-187. doi:10.1016/j.bbcan.2008.05.003
2. Lowenstein EJ, et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 1992;70(3):431-442. doi:10.1016/0092-8674(92)90167-B
3. McDonald CB, et al. Structural insights into the binding of the human receptor tyrosine kinase MET by its ligand stromal cell-derived factor 1α (SDF-1α). J Biol Chem. 2015;290(13):7719-7732. doi:10.1074/jbc.M114.631126