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RIPK2 (K47A), Unactive

Recombinant human RIPK2 (K47A) (1-299) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R08-16G


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Catalog No. Pack Size Price (USD)
R08-16G-20 20 ug $314
R08-16G-50 50 ug $545
R08-16G-BULK BULK Contact Us  


Overview:

RIPK2 (RIP2; RICK) is a death domain-containing protein kinase encoding with predicted 540-amino acid protein. It contains an N-terminal serine/threonine kinase catalytic domain and a C-terminal caspase activation and recruitment domain. RIPK2 is thought to regulate apoptosis induced by the FAS receptor pathway (1). RIPK2 has been shown to specifically interact with the CARD of ICE/caspase-1 and this interaction correlates with the processing of pro-caspase-1 and the formation of the active caspase-1 p20 (2).


Gene Aliases:

RICK; RIP2; CARD3; CARDIAK


Genbank Number:


References:


1. Inohara, N. et al: RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem. 273: 12296-12300, 1998. Note: Erratum: J. Biol. Chem 273: 18675 only, 1998.

2. Thome, M. et al: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol. 8: 885-888, 1998.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~59 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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  RIPK2, Active, R08-11G

  RIPK3, Active, R09-10G

  RIPK5, Active, R27-10G


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