Full-length recombinant human TEC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T03-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T03-10G-05 | 5 ug | $226 | |
T03-10G-10 | 10 ug | $325 | |
T03-10G-BULK | BULK | Contact Us |
Overview:
TEC is a member of the Tec family of non-receptor protein-tyrosine kinases that are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. TEC is an integral component of T cell signaling and has a distinct role in T cell activation. Defects in TEC may be associated with myelodysplastic syndrome. TEC plays a crucial role in regulating FGF2 secretion under various physiological conditions (1) and it inhibits CD25 expression in human T-lymphocyte (2).
Gene Aliases:
PSCTK4, MGC126760, MGC126762
Genbank Number:
References:
1. Ebert,A.D.et.al: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic 11 (6), 813-826 (2010).
2. Susaki,K.et.al: TEC protein tyrosine kinase inhibits CD25 expression in human T-lymphocytes. Immunol. Lett. 127 (2), 135-142 (2010)
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~103 kDa
There are no related publications available for this product.
Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Receptor Tyrosine Kinases
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