Recombinant human MLK4 (114-420) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M48-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M48-11G-05 | 5 ug | $226 | |
M48-11G-10 | 10 ug | $325 | |
M48-11G-BULK | BULK | Contact Us |
Overview:
MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas (1). MLK4 is a negative regulator of TLR4 (2).
Gene Aliases:
dJ862P8.3; KIAA1804; RP5-862P8.2; MAP3K21
Genbank Number:
References:
1. Nagase, T.et.al;: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001.
2. Seit-Nebi, A. et.al: MLK4 has negative effect on TLR4 signaling. Cell. Molec. Immun. 9: 27-33, 2012.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~61 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cell Cycle, JNK/SAPK Pathway, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601