Recombinant human c-MER (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M51-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M51-11G-05 | 5 ug | $226 | |
M51-11G-10 | 10 ug | $325 | |
M51-11G-BULK | BULK | Contact Us |
Overview:
c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family (1). The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product (2).
Gene Aliases:
MER, MERTK, MGC133349
Genbank Number:
References:
1. Graham, D. K. et al: Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5: 647-657, 1994.
2. Gal, A. et al: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nature Genet. 26: 270-271, 2000.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~58 kDa
Kambayashi T et al., TAM receptors attenuate murine NK cell responses via E3 ubiquitin ligase Cbl-b
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Abu-Thuraiaa Afnan et al., Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion Molecular and Cellular Biology October 2014 10.1128/MCB.00764-14
et al., Regulation of ferredoxin-catalyzed photosynthetic phosphorylations. Proceedings of the National Academy of Sciences of the United States of America December 1975
Cardiovascular Disease, Inflammation, Receptor Tyrosine Kinases
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