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SHIP1, Active

Recombinant full length human SHIP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P08-20G


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Catalog No. Pack Size Price (USD)
P08-20G-05 5 ug $226
P08-20G-10 10 ug $325
P08-20G-BULK BULK Contact Us  


Overview:

The SH2-containing inositol-5′-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.


Gene Aliases:

INPP5D, SHIP, hp51CN, SIP-145, MGC142140, MGC142142


Genbank Number:


References:


1. Hamilton MJ, et al: Role of SHIP in cancer. Exp Hematol. 39(1):2-13, 2011.

2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438–445, 1996.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

144~160 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Inflammation, Lipid Kinases


RELATED PRODUCTS


  SHIP2, Active, P09-20G

  Phosphatase Dilution Buffer III, P23-09

  Phosphatase Assay Buffer III, P03-09


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