The SH2-containing inositol-5′-phosphatase 2 (SHIP2) belongs to the family of the mammalian inositol polyphosphate 5-phosphatases that catalyze the dephosphorylation of phosphoinositides and inositol phosphates with a phosphate at 5-position of the inositol ring. In addition to the N-terminal SH2 domains and N- and C-terminal proline-rich regions with consensus sites for SH3 domain interactions, SHIP2 also contains an SAM domain in the C-terminus interacting with the EphA2 receptor and with a PI 3-kinase effector protein regulating both Arf and Rho GTPases, ARAP3.
1. Pesesse X, et al: Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. Biochem Biophys Res Commun. 239(3): 697-700, 1997.
2. Zhuang G, et al: Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. J Biol Chem. 282(4): 2683-94, 2007.
3. Raaijmakers JH, et al: The PI3K effector Arap3 interacts with the PI (3,4,5) P3 phosphatase SHIP2 in a SAM domain-dependent manner. Cell Signal. 19(6): 1249-57, 2007.
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gregor T et al., The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases Science Signaling September 2018 10.1126/scisignal.aap8608
R Stenton Grant et al., Characterization of AQX-1125, a small-molecule SHIP1 activator British Journal of Pharmacology March 2013 10.1111/bph.12039
AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, Lipid Kinases