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PTPRB, Active

Recombinant human PTPRB (1552-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P49-21G


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Catalog No. Pack Size Price (USD)
P49-21G-05 5 ug $226
P49-21G-10 10 ug $325
P49-21G-BULK BULK Contact Us  


Overview:

PTPRB contains multiple repeated fibronectin type-lll domains extracellularly, a single transmembrane segment and only one protein tyrosine phosphatase (PTP) domain intracellularly, and thus belongs to receptor type PTP family (1). PTPRB negatively regulates angiogenesis and blood vessel remodeling via interacting with vascular growth factor tyrosine kinases such as TIE2, CDH5, and KDR (2). PTPRB has been reported to be one of the recurrent mutations in angiosarcoma tumors (3).


Gene Aliases:

PTPB, HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA


Genbank Number:


References:


1. Crossland S. et al: Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase. Biochem J. 1996 Oct 1;319 ( Pt 1):249-54.

2. Mantilidewi KI. et al: Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation. J Biol Chem. 2014 Mar 7;289(10):6451-61.

3. Behjati S, et al: Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet. 2014 Apr;46(4):376-379.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

116 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Invasion/Metastasis, Phosphatases


RELATED PRODUCTS


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