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CDC25B, Active

Full-length recombinant human CDC25B was expressed in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C04-20BG


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Catalog No. Pack Size Price (USD)
C04-20BG-05 5 ug $226
C04-20BG-10 10 ug $325
C04-20BG-BULK BULK Contact Us  


Overview:

CDC25B (also known as cell division cycle 25 homolog B) is a member of the CDC25 family of phosphatases that activate the cyclin dependent kinase CDC2 by removing two phosphate groups. CDC25B is required for cell entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. Cdc25B is the first genetic model for studying the mechanisms regulating prophase arrest in vertebrates (1). The regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation (2).


Gene Aliases:

none


Genbank Number:


References:


1. Lincoln, A. J. et.al: Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nature Genet. 30: 446-449, 2002.

2. Bulavin, D. V. et.al: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411: 102-107, 2001.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  CDC25A, Active, C04-20G

  CDC25C, Active, C04-20CG

  CDC7/DBF4, Active, C26-10G

  CDC7 Protein, C26-30G


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