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PTPRF (LAR), Active

Recombinant human PTPRF (1275-1897) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. P53-21G


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Catalog No. Pack Size Price (USD)
P53-21G-05 5 ug $226
P53-21G-10 10 ug $325
P53-21G-BULK BULK Contact Us  


Overview:

PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains (1). PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance (2).


Gene Aliases:

LAR


Genbank Number:


References:


1. Ahmad, F. et al: Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. J. Biol. Chem. 272: 448-457, 1997.

2. Tsujikawa, K. et al: Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor. Molec. Endocr. 15: 271-280, 2001. J. 2003 Aug 15;22(16):4121-31.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~93 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Invasion/Metastasis, Phosphatases


RELATED PRODUCTS


  PTPRM (PTP- mu) Protein, P58-35G

  Thr-phosphopeptide, T69-58

  PTPRE, Active, P52-21G


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