Recombinant human HTRA1 (161-480) protein was expressed in E. coli cells using an N-terminal His-tag.
Catalog No. H531-31H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
H531-31H-20 | 20 ug | $215 | |
H531-31H-50 | 50 ug | $435 | |
H531-31H-BULK | BULK | Contact Us |
Overview:
HTRA1 is a serine protease. HTRA1 targets a variety of proteins (1 & 2), including fibronectin (induce synovial cells to up-regulate MMP1 and MMP3 production), proteoglycans (release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space), IGF-binding proteins (regulates the availability of insulin-like growth factors) and TSC2 (leads to the activation of TSC2 downstream targets). HTRA1 relates to age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss (3).
Gene Aliases:
ARMD7; CARASIL; HtrA; L56; ORF480; PRSS11
Genbank Number:
References:
1. Hu S.I. et.al: Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. J. Biol. Chem. 273:34406-34412 (1998).
2. Grau S. et.al: The role of human HtrA1 in arthritic disease. J. Biol. Chem. 281:6124-6129 (2006).
3. Yang, Z. et.al: A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 314: 992-993, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
38 kDa
There are no related publications available for this product.
Cell Cycle, Neurobiology, Ser/Thr Kinases
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