Recombinant full-length human Catenin alpha was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C05-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C05-30G-20 | 20 ug | $215 | |
C05-30G-50 | 50 ug | $435 | |
C05-30G-BULK | BULK | Contact Us |
Overview:
Catenin α is a novel actin-binding and -bundling protein. Catenin α is responsible for organizing and tethering actin filaments at the zones of E-cadherin-mediated cell-cell contact (1). Monomeric Catenin α can bind strongly to E-Cadherin-β-Catenin, whereas the dimer preferentially binds actin filaments. Different molecular conformations are associated with these different binding states, indicating that Catenin α is an allosteric protein. Catenin α directly regulates actin-filament organization by suppressing Arp2/3-mediated actin polymerization, likely by competing with the Arp2/3 complex for binding to actin filaments (2)
Gene Aliases:
CTNNA1, CAP102, FLJ36832
Genbank Number:
References:
1. Rimm, D L. etal: Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8813-7.
2. Drees, F. et al: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell. 2005 Dec 2;123(5):903-15.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~123 kDa
Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, PKA/PKC Pathway, WNT Signaling
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