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Cantharidin

Phosphatase PP2A Inhibitor
Catalog No. P16-902C


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Catalog No. Pack Size Price (USD)
P16-902C-20 20 mg $59
P16-902C-100 100 mg $193
P16-902C-BULK BULK Contact Us  


Overview:

Inhibits protein phosphatase 2A (Ki=0.19 uM) and PP1 (Ki=1.1 uM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin2. Arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK13. Cell permeable.

References:


1. RE Honkanen FEBS Lett. 1993 330:283

2. MY Wu et al. Oncol. Rep. 2014 32:513

3. FR Gong et al. Oncotarget 2015 6:18469


CAS Registry Number:

56-25-7


Molecular Formula:

C10H12O4


Appearance:

White powder


Molecular Weight:

196.20


Purity:

>98% (HPLC)


Solubilization:

May be dissolved in DMSO (20 mg/ml); or ethanol (5 mg/ml)


Aliases:

3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione


Storage and Stability:

Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 weeks.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases



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