Cantharidin
Phosphatase PP2A Inhibitor
Catalog No. P16-902C
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P16-902C-20 | 20 mg | $90 | |
| P16-902C-100 | 100 mg | $335 | |
| P16-902C-BULK | BULK | Contact Us |
Phosphatase PP2A Inhibitor
Catalog No. P16-902C
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P16-902C-20 | 20 mg | $90 | |
| P16-902C-100 | 100 mg | $335 | |
| P16-902C-BULK | BULK | Contact Us |
Overview:
Inhibits protein phosphatase 2A (Ki=0.19 uM) and PP1 (Ki=1.1 uM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin2. Arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK13. Cell permeable.
References:
1. RE Honkanen FEBS Lett. 1993 330:283
2. MY Wu et al. Oncol. Rep. 2014 32:513
3. FR Gong et al. Oncotarget 2015 6:18469
CAS Registry Number:
56-25-7
Molecular Formula:
C10H12O4
Appearance:
White powder
Molecular Weight:
196.20
Purity:
>98% (HPLC)
Solubilization:
May be dissolved in DMSO (20 mg/ml); or ethanol (5 mg/ml)
Aliases:
3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
Storage and Stability:
Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 weeks.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases
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