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NSC-663284

Cdc25 Phosphatase Inhibitor
Catalog No. C04-902


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Catalog No. Pack Size Price (USD)
C04-902-5 5 mg $116
C04-902-25 25 mg $435
C04-902-BULK BULK Contact Us  


Overview:

Potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation2. Inhibits the growth of a variety of human tumor cell lines3. Acts via irreversible oxidation of the catalytic cysteine of CDC254.

References:


1. JS Lazo et al. J. Med. Chem. 2001 44:4042

2. L Pu et al. J. Biol. Chem. 2002 277:46877

3. Y Han et al. J. Pharmacol. Exp. Ther. 2004 309:64

4. M Brisson et al. Mol. Pharmacol. 2005 68:1810


CAS Registry Number:

383907-43-5


Molecular Formula:

C15H16ClN3O3


Appearance:

Red powder


Molecular Weight:

321.8


Purity:

>98%


Solubilization:

May be dissolved in DMSO (15 mg/ml); or ethanol (55 mg/ml)


Aliases:

6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases



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